Abstract

Chronic myeloid leukemia (CML) is associated with BCR-ABL1 fusion gene located on chromosome 22 as a result of a t(9;22)(q34;q11.2) translocation in about 90% of the patients. Also, coexistence of the t(9;22) and inv(16) chromosomal aberrations is a rare occurrence that has been described in CML (mainly the myeloid blast phase [CML-BP]), de novo AML, and a few cases of therapy-related AML (t-AML). We describe a 22 years old male in primary blast crisis of CML as initial presentation with coexistence of the t(9;22) and inv(16). Majority of cases, in which these abnormalities coexist are CML-BP, which is typically characterized by an aggressive clinical course rapid disease progression and resistance to chemotherapy.

Keywords: CML, inv(16), blast crisis, t(9;22), leukaemia

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How to Cite
Abbas, A., Kalas, M., & Raidullah, E. (2023). Rare Coexistence of Inv(16) and T(9;22) in Patient with Chronic Myeloid Leukaemia Presenting as Blast Crisis. International Journal of Innovative Research in Medical Science, 8(09), 417–419. https://doi.org/10.23958/ijirms/vol08-i09/1747

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Copyright © 2023 Aymen Abbas Mutaz Kalas Emadullah Raidullah this is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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This work is licensed under a Creative Commons Attribution 4.0 International License.