Abstract

After showing the potential involvement of magnesium chloride to stabilize tissue mast cells involved in the etiology of seborrheic dermatitis, the case of a patient with atopic hand dermatitis confirms the efficacy of a 10% magnesium chloride ointment. This observation is confirmed by a recent Japanese study showing the effectiveness of magnesium chloride and zinc chloride solutions in stabilizing rat peritoneal mast cells. Thus, in vitro research confirms the in vivo clinical observations. The local treatment of seborrheic and atopic dermatitis should therefore be redirected towards a more effective strategy without potential side effects, thus marking a great progress in dermatology.

References

1. Sudan, B. J. L. (2024). Mast Cells, Magnesium Chloride and Seborrheic Dermatitis as an Allergic Skin Disease. International Journal of Innovative Research in Medical Science, 9(09), 511–516. https://doi.org/10.23958/ijirms/vol09-i09/1960
2. Sudan, B.J.L., Sterboul J. (1980). Dermite séborrhéique et cromoglycate de sodium [Seborrheic dermatitis and sodium cromoglycate], Cutis (Paris), 4, 81-85. https://www.researchgate.net/publication/378157111_Dermite_seborrheique_et_cromoglycate_de_sodium
3. Sudan, Bernard (2021). Magnesium of Dead Sea salts as a new approach for the treatment of seborrheic dermatitis. Available online: https://bernardsudan.net/dead-sea-salts-as-a-new-approach-for-the-treatment-of-seborrheic-dermatitis/ (22/07/2021)
4. Sudan, Bernard (2025). YouTube channel Available online: https://www.youtube.com/@bernardsudan4026
5. Kazama, Itsuro & Sonobe, Hiroyuki & Shida, Junko. (2025). Magnesium and Zinc Dose-Dependently Stabilize Rat Peritoneal Mast Cells and Enhance the Effects of Adrenaline. Cellular Physiology and Biochemistry. 59. 465-477. https://doi.org/10.33594/000000793
6. Sudan, B.J.L. (2025) Nicotine Hypersensitivity in Inflammatory Dermatoses: A Systematic Review of Evidence for Nicotine as a Cutaneous Hapten. Bioscientia Medicina: Journal of Biomedicine and Translational Research, 9(7), 7941-7953. https://doi.org/10.37275/bsm.v9i7.1325